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sparsentan will decrease the level or influence of modafinil by influencing hepatic enzyme CYP2C19 metabolism. Use Caution/Watch. Sparsentan (a CYP2C19 inducer) decreases publicity of CYP2C19 substrates and lessens efficacy linked to these substrates.Modafinil’s suppression of brain CYP2C9 could demonstrate modafinil’s capability to lessen reac